You have probably heard of Predimed study. It was an extraordinary study which cemented the benefits of Mediterranean diet. One of the principal investigators, professor Jordi Salas-Salvadó kindly answered some questions I had on my mind regarding the Study.

Jordi Salas-Salvadó works as a professor of nutrition and director of human nutrition unit at Rovira i Virgili University, Reus, Spain.

Reijo Laatikainen: First of all, congratulations for the great results and being able to carry out such a huge study successfully! Is the research team happy with the results? 

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Predimed study: Mediterranean diet prevents cardiovascular events

by Reijo Laatikainen on February 27, 2013

A large Spanish randomized controlled trial on Mediterranean diet cemented the cardiovascular benefits of Mediterranean diet pattern. Mediterranean diet, supplemented either with extra virgin olive oil or nuts, reduced the risk of by cardiovascular events by 30 % in people already treated with many drugs, like statins. The control diet was lower in fat and higher in carbohydrates and also relatively low in saturated fat. The control group did not manage to reduce the fat intake as targeted, but this is not unusual. In many long term trials, like in WHI, DPS and DPP studies fat reduction was much less than intented. Majority of the middle aged or elderly western people are not able to reduce fat content of their diet substantially. (Yes, of course some can, and those who can are likely to do well on very low fat plant based diet.)

The control diet also contained relatively much fruit and vegetables.  The amount of  red and processed meat was rather low when compared to usual western diets. Bearing these facts in mind, the favourable outcomes of Mediterranean diet are even more striking. More data on cognition, cancer and risk factors are expected later.

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Sydney Diet Heart Study, a die hard story

by Reijo Laatikainen on February 16, 2013

After  40 years of its ending, the main results of Sydney Diet Heart Study are finally published. This is the only published randomized trial where saturated fat based diet outperfoms PUFA based diet in terms of coronary heart disease deaths. However, the modern margarines, canola oil, flax seed oil and nuts are healthy. Read the slides for details and understanding why the results should be interpreted with care.

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Why nuts do not cause weight gain as expected

by Reijo Laatikainen on January 3, 2013

In the last post I elaborated on the dietary factors that are linked to weight management in long term. Nuts seemed to protect from weight gain. Nuts are packed with calories; so: how is this possible? This slide deck summarizes the scientific evidence in humans.

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Which foods help in weight maintenance? A systematic review

November 22, 2012

A research team behind Nordic dietary recommendations 2012 have put together a solid scientific package regarding diet and weight maintenance. There is so much fuss about different weight loss regimens but less on how to maintain the weight; either the current normal weight or the new weight after inital weight loss period.  This systematic review concluded [...]

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Red and processed meat vs dairy. Suprising data from cohorts

November 14, 2012

Red and processed meat foods are linked to many diseases. This slide deck summarizes the overwhelming evidence from cohort studies and some RCTs showing the adverse effects of red meat on diabetes, strokes, heart disease and colorectal cancer. In contrast, high intake of dairy is linked to improved health outcomes. This is unexpected because dairy [...]

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Why grains may cause bowel symptoms?

October 17, 2012

There are myriad blog posts and “expert” opinions on gluten and on its possible detrimental effect on us. Many of these writings are based on anecdotal data and myths -not on solid scientific evidence in humans. However, a recent randomized trial showed that gluten may cause bowel symptoms in a small fragment of patients with sensitive [...]

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What is the evidence on fatty acids and inflammation?

August 21, 2012

There’s been a long dispute on the effects of omega-6 fatty acids on low grade inflammation. Many supporters of paleolithic & low carb diet claim that excessive consumption of omega-6 fatty acids leads to highly proinflammatory state in body and is the root cause of modern diseases such as atherosclerosis, cancer, diabetes. Now this belief [...]

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Low carb diet and health. What about kidneys, heart, metabolic and gastrointestinal health?

August 21, 2012

These slide decks demonstrate the effects of low carb diets on various health parameters. Because there is no randomized long term morbidity and mortality study done on low carb diet, the conclusions need to be done on the basis of short term randomized trials (surrogate markers) and prospective cohorts. Low carb diet and cancer from [...]

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Long term weight loss and low carb diets

August 21, 2012

This slide deck summarizes the results from randomized controlled trials lasting minimum 2 years. See also my slide decks at Slideshare regarding low carb diet & health.   Low carb diet and long term weight loss from pronutritionist Efficacy of low carbohydrate diet seems to be similar to lower fat diet. In shorter trials low [...]

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